Located in the eastern part of the Tarim Basin, Lop Nur Lake is one of the largest playa lakes in the world. The chemical sequence of Lop Nur salt lake is remarkably different from many non-marine and marine chemical sedimentary sequences except for that of Tertiary paleo-salt lake in Jianghan Basin, Hubei Province, which shows some similarity with the sedimentary sequence of Lop Nur salt lake. Therefore, the coupling of continuous drying and supply variation might have been responsible for the formation of the special and complex chemical sedimentary sequence in Lop Nur salt lake.