There was much controversy for long over the formation age of the Huluhe Group in eastern part of Qilian orogenic belt. Choosing the meta-detrital rocks in the Huluhe Group as study objects, this article uses LA-ICP-MS zircon U-Pb isotope chronology to study the formation age and material source of the Huluhe Group. The results show that the detrital zircons isotope ages of the two samples from the Huluhe Group and the age of the granite intruded in it show that the sedimentary age of the Huluhe Group ranges from 447~434 Ma, mainly the early Silurian. The zircon age spectrum can evidently divided into four groups: Sinian-Early Paleozoic age group from 426~595 Ma; Neoproterozoic age group from 738~981 Ma; Mesoproterozoic age group from 1 000~1 913 Ma; Paleoproterozoic-Neoarchaean age group from 2 053~2 872 Ma, respectively.