Based on the global distribution of magmatic Ni-Cu-PGE sulfide deposits and the relationship between this type deposits and large igneous provinces (LIPs), the authors suggested that the location of magmatic Ni-Cu-PGE sulfide deposits is related to lithospheric architecture. At crustal levels, this relationship is manifested by a close proximity to craton and paleocraton margins. Deposits are associated with mafic-ultramafic rocks and many show a close spatial and temporal relationship with coeval igneous migration. A craton-margin model for the genesis of magmatic Ni-Cu-PGE sulfide deposits is proposed in this paper. The advantages of the craton margin for the formation of magmatic Ni-Cu-PGE sulfide deposits were summarized.