Two granite weathering profiles developed in the south of Guangdong Province were studied in this paper. The concentrations of some major and heavy metal elements were determined by the authors. It can be concluded that the soil-forming process of the study area is a continual process of losing Na, Mg, K and Ca, the soil has been highly weathered, and the variation trend of heavy metal concentrations in two profiles is consistent with that of the major elements. These characteristics are of great significance in studying the cause of the phenomenon that the concentrations of As, Pb in deep soil are higher than those in top soil in Guangdong Province.