As the most typical zones of ground subsidence in Su-Xi-Chang of Yangtze River Delta, their actuality and formation mechanism of ground subsidence were analyzed. Through selective preference for the evaluating indicators in the system, an indicator system of risk evaluation on ground subsidence was established according to the practical situation in the areas along western Wuxi City to southern Jinagyin City. The suggestions of ground subsidence risk control were offered based on the evaluation of susceptibility and vulnerability of ground subsidence using GIS method to evaluate ground subsidence risk.