The Changxing-Fenghua Fault (CFF) is a regional fault trending in NW-SE, which diagonally goes across the Hangzhou Bay region. The authors analyzed the distribution and activity of the CFF in the Mesozoic and Cenozoic according to the TM remote sensing image, aeromagnetic anomaly map, Bouguer gravitational anomaly map and artificial seismic profiles. Therefore, the CFF is a tenso-shear fault and belongs to the NW-trending active fault zones of the eastern Chinese continent in the Mesozoic and Cenozoic.