In this paper, in order to restrict the timing of mineralization, direct Re-Os isotopic dating on molybdenites collected from the skarn ore in the Xingjiashan molybdenum-tungsten deposit have been carried out. Based on the results of Re-Os isotopic dating presented in this paper and available isotopic data published in previous studies, the authors suggest that the mineralization in the Jiaodong Peninsula since Mesozoic could be divided into four mainly phases: the first is the copper-molybdenum multi-metal mineralization phase at ca. 165~155 Ma; the second is the gold mineralization phase at ca. 137~110 Ma; the third is the copper-molybdenum-lead-zinc multiple metal mineralization phase at ca. 120~110 Ma; and the fourth is the gold-silver-lead-zinc multi-metal mineralization phase at ca. 100~75 Ma. They are respectively responding to the multiphase granitoid magmatic actions during early-late Yanshanian.