Based on the regional metallogenic setting, ore-controlling structure and distribution of Pb-Zn deposits, Pb-Zn deposits in Qinling of Shaanxi were divided into Fengtai, Shanzha, Zhenxun and Mayuan Pb-Zn ore concentration areas from north to south. Pb-Zn deposits mainly occurred in Devonian, Silurian and Sinian strata, and the types were SEDEX and MVT. Isotope geochemistry and trace elements geochemistry in ore mineral were summarized, and material source of mineralization and forming environment of mineralization basin of Pb-Zn deposit in Qinling of Shaanxi were discussed, and the geodynamic process was studied. The results showed that ore sulfur of Pb-Zn deposit in Qinling of Shaanxi mainly came from seawater sulfate, ore lead mainly came from the upper crust, and ore-forming hydrothermal fluid mainly came from precipitation; large-scale mineralizations in Fengtai, Shanzha and Zhenxun Ph-Zn ore concentration areas were controlled by the continental extensional environment, which was caused by the subduction of Yangtz Plate and Qinling microplateseparately along Mianlue band and Shangdan band in Late Palaeozoic; the mineralization in Mayuan Pb- Zn ore concentration area was controlled by the extensional lithosphere geodynamic setting in the northern edge of Yangtze Plate after Jinning movement.