Yangla large copper deposit, located in Deqin county, northwestern Yunnan, is a typical deposit in the Jinshajiang tectonic belt, and there is no unified understanding on its ore genesis and metallogenic model. In this paper, based on the stratigraphic subdivision, magmatic rocks and tectonic setting, metallogenic material and ore-forming fluid, metallogenic epoch and ore genesis, we summarized the progress in the study on Yangla large copper deposit, and proposed a new metallogenic model, hydrothermal sedimentation-magrnatic hydrothermal mineralization-structure-hydrothermal transformation. In Hercynian period, hydrothermal sedimentation provided partial ore forming material for copper deposit, but did not formed the scale copper ore-body. In late Indo-Sinian period, magmatic hydrothermal mineralization formed the skarn-type ore-body, as the main ore body of Yangla deposit, and the residual magma formed quartz porphyry and veins and porphyry copper ore-body in a shallow- seated environment. During Yenshanian and Himalayan period, structure-hydrothermal transformation further transformed early ore-body into rich ore-body or lean ore-body, and the early ore-body was broken into different ore-section in space.