Paleogene system in the central part of Huanghua Depression undergoes two evaluative phases of downfaulted and depression basin, and its structural activity is tightly relative to sedimentation. The second-third member of the Shahejie Formation is the phase of downfaulted basin, sedimentary facies and thickness is controlled by boundary and interior consedimental faults. Fan delta system and inshore subaqueous fan system are extensive development. Paleogene palaeostructral activity in the central part of Huanghua Depression and its control on settlement system and skeletal sand are studied to find the arrangement relation between reservoir and fracture system. It’s of great importance to next exploration for subtle reservoirs.