Based on the study of the structural deformation, the occurrence measurement of outcropped conjugate shear joints, and previous research results, the paleo-tectonic stress field of the Dazhou volcanic faulting basin and its relationship to uranium mineralization was studied using mathematical statistics. Four stages of tectonic stress undergone are summarized. And controlling of each stage over uranium mineralization is also discussed. Finally, this study suggests that late three tectonic stages have close relation to the uranium mineralization, i.e. the Moshishan tectonic stress field provided space for mineralization, the Qujiang stage provided conduits, and Eocene-Oligocene tectonic stress destroyed or reformed previously-formed orebodies.