Based on 740 focal mechanism solutions of ML≥2.5 earthquakes occurred during Jan. 1998 to Jan. 2009 in middle Xiaojiang fault and its adjacent area, the studied region was divided into sub-regions, and temporally further divided into phases with the larger earthquakes as boundary of the sub-regions. After removal of the larger earthquakes this paper inverted the focal mechanism data with the method of Gephart for the stress in main phase of each sub-region. The result indicates that the azimuth of maximum principal stress σ1 in 4 temporal phases of the sub-region A is approximately NNW-SSE, and in northern part of sub-region B are approximately NNW-SSE, WNW-ESE and ENE-WSW. The azimuth of σ1 in southern part of sub-region B is approximately NNW-SSE.