According to local conditions, the transferring forms of uranium and strontium are UO2(CO3)2-2 and Sr2+, respectively, but their performances are opposite, and the disposal layers are strong surface oxidation zones and the rain infiltration is also intensive, so reductive barriers should not be built. Therefore, the barriers for uranium and strontium are orderly constructed: anion adsorption barrier (Ⅰ) and cation adsorption barrier (Ⅱ), to make up of the double barriers enabling a continuous infiltration. The sand materials for barrier construction can be taken from the disposal site nearby and the cost is very low. The results of simulation experiment in the laboratory show that the distribution coefficients are in the 103 magnitude when uranium and strontium radionuclides pass through the barriers. This study can provide a technical support for protecting the disposal site safety and economically treating radioactive wastes.