Based on the method of using a number of seismic activity parameters to determine activity features of fault zone segments, current seismic activity and seismic risk features of different segments of Cenozoic tectonic deformation zones in Anhui Province are analyzed. The results show that: there are nine segments with different activity features in Cenozoic tectonic deformation of Anhui Province, among which the current activity features of Huoqiu-Fengtai, Tongling-Ningguo, Mingguang-Feidong segments are in a relatively high stress status and should belong to potential moderate-strong earthquake risk segments with certain strain accumulation; the present activity features of other six segments are in a middle or low stress background and are characterized by frequent or sparse small earthquake sliding, and the possibility of future recurrence of moderate-strong earthquakes is small.