The thick loess area in southwest depression of Tarim Basin is always one of the most complex regions for seismic survey. Being covered with thick loess, the shooting and receiving conditions are poor, resulting in severe absorption and attenuation of seismic waves as well as low signal-to-noise ratio. In order to find out Kexi-2 structure found by non-seismic prospecting, such 2-D seismic acquisition techniques as array shooting, long geophone array receiving and wide-line acquisition ones are all applied in this area. The results show that the seismic profile acquired is of much higher quality than ever before, proving these techniques are effective and practicable.