Ni, Cu and PGE are very important in the study of origin and evolution of mantle derived magmas and the formation of the related magmatic sulfide deposits, because their geochemical natures are different from other trace elements. Ni, Os, Ir and Ru are compatible elements, and Cu and Pd are incompatible in sulfur under-saturated magmas. Thus, they may be differentiated during fractional crystallization of the sulfur under-saturated basaltic magma. In contrast, all of these metals will be concentrated in sulfide liquid while sulfur saturation is reached. Particularly, minor sulfide removal will result in PGE-depletion in the basaltic magma because PGE have very high sulfide liquid/silicate melt partition coefficients. Therefore, PGE are the most sensitive tracers for sulfide segregation. Ni, Cu and PGE are also very important in the studies of key factors of the formation of magmatic sulfide deposits, which resulted from the evolution of mantle derived magmas.