The Cuihongshan Pb-Zn polymetallic deposit, a skarn type, occurred in the contact metamorphic zone between the granites and Lower Cambrian Qianshan metamorphic rocks of the Xilin Group. Summarized the geochemical features of the granitics in this area, the authors proposed that the granite have the transition from I-type to A-type, and the zircon SHRIMP U-Pb dating method yielt two ages of (192.8±2.5) Ma and (199.0±3.1) Ma for the biotite monzogranite and monzogranite respectively. The result reveals that Pb-Zn polymetallic deposit have a very closely relation with magmatic activity, and the ore-forming age is corresponding to late Indosinian-early Yanshanian.