A combined study of U-Pb zircon dating, whole-rock chemical and Sr-Nd isotopic composition was carried out for the Meiwu pluton in the middle part of the west Qinling. U-Pb zircon dating shows that the Meiwu pluton intruded at 245-242 Ma. The Meiwu pluton, a complex batholith, is composed of quartz-diorite, granodiorite and biotite granite, with abundant mafic magmatic enclaves(MMEs) in the granodirite. The different rock types in the Meiwu pluton are characterized by distinct chemical evolution trend. Geochemical and Sr-Nd isotopic composition indicate the magma of the Meiwu granodiorite and biotite granite was dominantly derived from crustal source.