The Fankou lead-zinc deposit occurs in Devonian carbonate platform. After systemic study of the carbon and oxygen isotope composition of rock and ore of ore-bearing strata, it shows that fading alteration in purple sandstone and the phenomenon of dolomitizationin in limestone are closely related with basin brine. The δ13C and δ18O value of carbonate cement in fading altered sandstone are similar to carbonate mineral in ores, which is rather low. Further research shows that the carbon and oxygen isotope feature of basin brine and ore-forming fluid are analogy, and basin brine is closely related with metallogensis. So in many aspects, the Fankou deposit is more likely to show the characters of Mississipi Valley-type. oft-com:office:office" />