The Bairendaba and Weilasituo ore deposits are two silver-polymetallic deposits discovered in eastern Inner Mongolia in recent years. Researches on the sulfur and lead isotopes of the sulfides from these two deposits are reported in this paper. It is shown that the δ34S values of the sulfides from the Bairendaba and the Weilasituo deposit vary from -4.0‰ to +1.6‰ and from -0.8‰ to +2.0‰, respectively, close to the sulfur isotopic composition of the magmatic hydrothermal fluid, suggesting that the sulfur in both the Bairendaba and the Wei-lasituo deposit were mainly derived from the magma. It is thus inferred that the lead in ores from these two deposits might have mainly come from the wall rocks of gneiss and deep magma.