LA-ICP-MS zircon U-Pb dating data of the Mesozoic granitoids from Lingquan, Baogedewula and Shanghulin basins in Manzhouli and Erguna area are obtained to constrain the regional tectonic evolution. Zircons from 12 representative granitoids are euhedral-subhedral in shape and display typical oscillatory zoning in CL images as well as high Th/U ratios of 0.31~3.63, implying their magmatic origin. The results indicate that the Mesozoic granitic magmatism in the region can be divided into three stages, i.e., the Middle Triassic, Early-Middle Jurassic, and Early Cretaceous magmatism. Combined with the lack of coeval volcanic rocks in the eastern Jilin-Heilongjiang provinces, the data suggest that these volcanic rocks could be formed under an extensional setting related to the evolution of the Mongol-Okhotsk orogen.