The Yuelianggou silver polymetallic deposit is located in the Ag - Au - Cu - Pb - Zn polymetallic ore belt, Xiongershan Mountains, Huaxiong platform margin depression. This paper presents the studies of regional metallogenie background,geological,geophysical and geochemical characteristics and metallogenie geological conditions of this deposit,and its metallogenie prospecting and prospecting significance. The result shows that the Taihua and Xionger groups metamorphic core complex and detachment faults at the contact site comprise the basic structural framework in the region. These structures exert a key control on the metal deposits, and the dome contact site between the Taihua Group and Xionger group is favorable for ore searching. It is thus inferred that doing research work in the areas of the detachment fault - metamorphic core complex will provide guidance significance for searching for similar deposits.