Based on analyses of geological background, ore body features and petro-geochemistry features, the authors preliminary dis- cussed the genesis of ore deposits in Chaliangzi ore district. The formation of ore bodies were related to sulfur-rich epithermal fluid. The fluid carried minerals and transported to the vantage point of fault zone, and then the minerals were deposited. In the superficial environment, primary ore body change into earthy ore that was rich in iron manganese oxide by secondary reformation. The rich iron manganese oxide could be the indicators for exploring cobalt ore.