The Lower Jurassic Ahe Formation sandstone characterized by low porosity and low permeability is the main reservoir in the Yinan-Tuzi area of the Kuqa Depression, within which the well-developed structural fractures serve as important migration pathways and accumulation spaces. On the basis of acoustic emission and rock mechanics parameter testing, considering the influence of faults on the fracture forming, we simulate the main fracture forming period paleostress field and predict the distribution of structural fractures with the constraints of cores using 3D finite element method. The simulation results show that the Yiqikelike anticlinal zone and the Well Yinan 2 area are the most favorable areas for structural fractures, with density 〉1.4 m-1. The structural fracture density decreases gradually towards the Tuzi area and south of Well Yinan 2 area, varying in the range of 0 to 0.4 m-1. The present study results can provide us new geological evidence for the fracture development evaluation, and reservoir prospecting and exploitation in the area.