Dongzhongla lead-zinc deposit in oft-com:office:smarttags" />Tibet is located in the north sub-zone of eastern section of Gangdise metallogenic belt. The studies show that the composition of S isotope in ore sulfides confined in a narrow variation range. The value of total 34S is 5.21‰, which present a characteristic of sulfur from magmatic origin. The Pb isotopic composition of ore sulfides is stable and the ore lead is ordinary common lead. Ore lead derived from magma, which came from partial melting of the upper crust in Early period of later-Yanshan and its pattern-age is about 131~134 Ma.