Evolution of major histocompatibility complex genes in mammals

详细信息    Evolution of major histocompatibility complex genes in mammals

• 出版日期：2002.
• 页数：147 p. :
• 第一责任说明：Katarzyna B. Miska.
• 分类号：a184.5 ; a161
• ISBN：0493744304(ebk.) :

MARC全文

02h0025446 20110922110800.0 cr un||||||||| 110922s2002 xx ||||f|||d||||||||eng | AAI3058941 0493744304(ebk.) : CNY371.35 NGL NGL NGL a184.5 ; a161 Miska, Katarzyna B. Evolution of major histocompatibility complex genes in mammals [electronic resource] / Katarzyna B. Miska. 2002. 147 p. : digital, PDF file. Source: Dissertation Abstracts International, Volume: 63-07, Section: B, page: 3160. ; Adviser: Robert D. Miller. Thesis (Ph.D.)--The University of New Mexico, 2002. Major Histocompatibility Complex class I (Mhc-I) molecules play an essential role in adaptive immune responses of all jawed vertebrates. Most studies characterizing mammalian Mhc-I genes have been carried out in members of a single mammalian subclass, the Eutheria, or placental mammals. In this study, research concerning evolution and structure of Mhc-I has been extended to members of the two other mammalian subclasses: marsupials and monotremes. This study focuses on two major aspects of Mhc-I (1) description of the number of Mhc-I loci in a single marsupial, Monodelphis domestica, and (2) characterization of monotreme Mhc-I genes. This study provides the first opportunity to study the evolution of Mhc-I genes in all three mammalian lineages.;Using a combination of cDNA and genomic analysis, sequences from three Mhc-I loci were identified in M. domestica. Two of the loci represent a recent Mhc-I gene duplication which occurred 2.9 to 3.7 million years ago. Efforts to characterize Mhc-I genes from the short-beaked echidna and the duck-billed platypus resulted in the first isolation of functional as well as non-functional, Mhc-I sequences from any monotreme. From phylogenetic analysis of Mhc-I sequences it is clear that mammalian Mhc-I genes are derived from three different ancestral Mhc-I genes. This pattern of evolution would require two rounds of duplications and deletions at the mammalian Mhc-I to account for the current Mhc-I genes present in each mammalian subclass. This research expands the knowledge of monotreme and marsupial Mhc-I, allows the analysis of Mhc-I evolution in all mammalian subclasses, and has significance for mammalian systematics. Major histocompatibility complex ; Mammals ; Marsupials Evolution. ; Phylogeny. ; Genome mapping. Electronic books. aeBook. aCN bNGL http://proquest.calis.edu.cn/umi/detail_usmark.jsp?searchword=pub_number%3DAAI3058941&singlesearch=no&channelid=%CF%B8%C0%C0&record=1 NGL Bs961 rCNY371.35 ; h1 bs1107