Anogenital Distance, a Biomarker of Prenatal Androgen Exposure Is Associated With Prostate Cancer Severity
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- 作者：Ana B. Maldonado-Cá ; rceles ; Carlos Sá ; nchez-Rodrí ; guez ; Eva M. Vera-Porras ; Juliá ; n J. Á ; rense-Gonzalo ; Juliá ; n Oñ ; ate-Celdrá ; n ; Paula Samper-Mateo ; Damiá ; n Garcí ; a-Escudero ; Marcos Torres-Roca ; Francisco Martí ; nez-Dí ; az ; Jaime Mendiola and Alberto M. Torres-Cantero
- 刊名：The Prostate
- 出版年：2017
- 出版时间：March 1, 2017
- 年：2017
- 卷：77
- 期：4
- 页码：406-411
- 全文大小：214K
- ISSN：1097-0045
文摘
Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity.