The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population
详细信息 查看全文
- 作者：Liang Huang ; Yin Mo ; Xuejin Sun ; Hualin Yu ; Hao Li ; Lichuan Wu and Ming Li
- 关键词：CACNA1C ; rs1006737 ; voxel-based morphometry ; gray matter ; Han Chinese
- 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：171
- 期：3
- 页码：396-401
- 全文大小：189K
- ISSN：1552-485X
文摘
The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations. In Han Chinese, rs1006737 is also strongly associated with schizophrenia, although the effects of the psychosis risk SNP on related brain functions and structures in this population remain unclear. Here, we examined the association of rs1006737 with gray matter volume in a sample of 278 healthy Han Chinese. A whole-brain voxel-based morphometry (VBM) analysis revealed a significant association in the region around right superior occipital gyrus (family-wise error corrected, P = 0.023). Our data provides initial evidence for the involvement of this psychosis genetic risk locus in brain structure variations in Chinese population, and calls for further investigations.