Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti-HBs in a population in Northeastern Brazil

详细信息    查看全文

• 作者：Ingrid de Campos Albuquerque ; Marinilde Teles Sousa ; Max Diego Cruz Santos ; Jomar Diogo Costa Nunes ; Maria José ; lia Diniz Moraes ; Michele Soares Gomes-Gouvê ; a ; Joã ; o Renato Rebelo Pinho ; Flair José ; Carrilho ; Lena Maria Barros Fonseca and Adalgisa de Sousa Paiva Ferreira
• 刊名：Journal of Medical Virology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：89
• 期：3
• 页码：458-462
• 全文大小：110K
• ISSN：1096-9071

文摘

Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs serological markers in individuals of Maranhão, Northeastern Brazil. Samples from a population-based study were evaluated for HBsAg, anti-HBs, and anti-HBc, and those that tested positive for simultaneous HBsAg and anti-HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti-HBs-positive profile (3.26%). The frequency of HBsAg and anti-HBs co-existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. J. Med. Virol. 89:458–462, 2017.