Blood pressure-lowering effects of sulodexide depend on albuminuria severity: post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies

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• 作者：Rik H. G. Olde Engberink ; Hiddo J. L. Heerspink ; Dick de Zeeuw and Liffert Vogt
• 刊名：British Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：82
• 期：5
• 页码：1351-1357
• 全文大小：555K
• ISSN：1365-2125

文摘

It has been suggested that sulodexide is able to lower blood pressure (BP). This may be attributed to its ability to restore the endothelial surface layer (ESL). As ESL perturbation is known to be related to the degree of kidney damage, we investigated whether albuminuria, reflecting ESL status, modified the BP-lowering potential of sulodexide.