Effects of TSLP on obstetrical and gynecological diseases

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• 作者：Yuan Zhang and Li-Ping Jin
• 刊名：American Journal of Reproductive Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：77
• 期：1
• 全文大小：470K
• ISSN：1600-0897

文摘

Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and was originally found to stimulate the growth and activation of B cells, but it is now shown to function on both hematopoietic and non-hematopoietic cell lineages. Despite a number of studies focusing on the role of TSLP in Th2 response for allergic disorders, it is becoming increasingly evident that TSLP may also be involved in multiple other disease states. This review will focus on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer.