Cover Picture: Protein Surface Mimetics: Understanding How Ruthenium Tris(Bipyridines) Interact with Proteins (ChemBioChem 2/2017)
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- 作者：Sarah H. Hewitt ; Dr. Maria H. Filby ; Dr. Ed Hayes ; Dr. Lars T. Kuhn ; Dr. Arnout P. Kalverda ; Dr. Michael E. Webb and Prof. Andrew J. Wilson
- 刊名：ChemBioChem
- 出版年：2017
- 出版时间：January 17, 2017
- 年：2017
- 卷：18
- 期：2
- 页码：151
- 全文大小：323K
- ISSN：1439-7633
文摘
The cover picture shows competitive inhibition of the cytochrome c/cytochrome c peroxidase interaction by highly functionalized ruthenium(II) tris(bipyridine) complexes. Inhibition is achieved through recognition of the solvent-exposed surface of cytochrome c using ruthenium(II) tris(bipyridine) complexes at the cytochrome c peroxidase binding site, as shown by 950 MHz natural-abundance NMR spectroscopy and detailed fluorescence studies. Binding is driven by entropy and electrostatic effects with additional potency arising in higher-affinity complexes from enthalpic contributions. More information can be found in the full paper by A. J. Wilson et al. page 223 in Issue 2, 2017 (DOI: 10.1002/cbic.201600552).