Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes

详细信息    查看全文

• 作者：Dr. Christian Borch Jacobsen ; Prof. Morten Meldal and Prof. Frederik Diness
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：23
• 期：4
• 页码：846-851
• 全文大小：852K
• ISSN：1521-3765

文摘

A general method for transition metal-free N-arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two-step synthesis of the antidepressant Vortioxetine.