Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers
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- 作者：Benjamin A. Katchman ; Rodrigo Barderas ; Rizwan Alam ; Diego Chowell ; Matthew S. Field ; Laura J. Esserman ; Garrick Wallstrom ; Joshua LaBaer ; Daniel W. Cramer ; Michael A. Hollingsworth and Karen S. Anderson
- 刊名：PROTEOMICS - Clinical Applications
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：10
- 期：7
- 页码：720-731
- 全文大小：1932K
- ISSN：1862-8354
文摘
Mutations in TP53 induce autoantibody immune responses in a subset of cancer patients, which have been proposed as biomarkers for early detection. Here, we investigate the association of p53-specific autoantibodies with multiple tumor subtypes and determine the association with p53 mutation status and epitope specificity.