In situ Raman vibration characterization and angle-dispersive X-ray diffraction (ADXD) measurements were performed on Y2O3/Eu3+ nanotubes to study its lattice change behavior under high pressure. The Raman vibration and lattice reflection both show changes in behavior near 8–10 GPa. The lattice of the cubic structure of Y2O3/Eu3+ nanotubes exhibits two different lattice states related to forms of the micro local atom arrangement. The lattice states resulted from the local disorder of the lattice due to pressure-induced deformation of the YO6 octahedra under the high pressure.