Further evidence to support bimodality of oestrogen receptor expression in breast cancer
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- 作者：Abir A Muftah ; Mohammed Aleskandarany ; Sultan N Sonbul ; Christopher C Nolan ; Maria Diez Rodriguez ; Carlos Caldas ; Ian O Ellis ; Andrew R Green and Emad A Rakha
- 刊名：Histopathology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：70
- 期：3
- 页码：456-465
- 全文大小：614K
- ISSN：1365-2559
文摘
Although oestrogen receptor (ER)-negative breast cancers (BCs) do not respond to hormone therapy, the response of ER-positive BCs is reported to be variable, which may suggest a dose-dependent effect. The aim of this study was to assess the pattern of ER expression in BCs at the protein (immunohistochemistry) and transcriptome (microarray-based gene expression) levels.