Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer
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- 作者：Martine P. Roudier ; Brian R. Winters ; Ilsa Coleman ; Hung-Ming Lam ; Xiaotun Zhang ; Roger Coleman ; Lisly Ché ; ry ; Lawrence D. True ; Celestia S. Higano ; Bruce Montgomery ; Paul H. Lange ; Linda A. Snyder ; Shiv Srivastava ; Eva Corey ; Robert L. Vessella ; Peter S. Nelson ; Aykut Ü ; ren and Colm Morrissey
- 刊名：The Prostate
- 出版年：2016
- 出版时间：June 15, 2016
- 年：2016
- 卷：76
- 期：9
- 页码：810-822
- 全文大小：6096K
- ISSN：1097-0045
文摘
The TMPRSS2-ERG gene fusion is detected in approximately half of primary prostate cancers (PCa) yet the prognostic significance remains unclear. We hypothesized that ERG promotes the expression of common genes in primary PCa and metastatic castration-resistant PCa (CRPC), with the objective of identifying ERG-associated pathways, which may promote the transition from primary PCa to CRPC.