Preliminary Application of Precision Genomic Medicine Detecting Gene Variation in Patients with Multifocal Osteosarcoma
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- 作者：Hao-qiang Zhang ; Ming-hui Li ; Peng Gao ; Ping-heng Lan ; Bo Fan ; Xin Xiao ; Ya-jie Lu ; Guo-jing Chen and Zhen Wang
- 刊名：Orthopaedic Surgery
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：8
- 期：2
- 页码：129-138
- 全文大小：1840K
- ISSN：1757-7861
文摘
The purpose of this study was to present our clinical experience of treating multifocal osteosarcoma (MFOS) in our center and gain more insight into the biology of this rare condition; in particular, to address with the help of precision genomic medicine the issue of whether the multiple osteosarcoma (OS) lesions in such patients are multi-centric or originate from one primary lesion and metastasize to other sites. Finally, we aimed to identify particular gene phenotypes and mutations that differentiate MFOS from OS with only one tumor.