Mild and Copper-Free Stereoselective Cyanation of gem-Difluoroalkenes by Using Benzyl Nitrile as a Cyanating Reagent
详细信息 查看全文
- 作者：Juan Zhang ; Chengyuan Xu ; Wei Wu and Prof. Dr. Song Cao
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：July 11, 2016
- 年：2016
- 卷：22
- 期：29
- 页码：9902-9908
- 全文大小：3835K
- ISSN：1521-3765
文摘
A novel copper-free highly stereoselective cyanation of gem-difluoroalkenes by using benzyl nitrile as a cyanating reagent with the assistance of tBuOLi under air atmosphere at room temperature was developed. A variety of versatile fluorinated alkenyl nitriles were obtained. The proposed mechanism involved the C−H bond oxidation, C−CN bond cleavage, and then nucleophilic vinylic substitution (SNV).