Efficient Batch-Mode Parahydrogen-Induced Polarization of Propane
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- 作者：Oleg G. Salnikov ; Dr. Danila A. Barskiy ; Dr. Aaron M. Coffey ; Dr. Kirill V. Kovtunov ; Prof. Igor V. Koptyug and Prof. Eduard Y. Chekmenev
- 刊名：ChemPhysChem
- 出版年：2016
- 出版时间：November 4, 2016
- 年：2016
- 卷：17
- 期：21
- 页码：3395-3398
- 全文大小：701K
- ISSN：1439-7641
文摘
We report on a simple approach for efficient NMR proton hyperpolarization of propane using the parahydrogen-induced polarization (PHIP) technique, which yielded ≈6.2 % proton polarization using ≈80 % parahydrogen, a record level achieved with any hyperpolarization technique for propane. Unlike in previously developed approaches designed for continuous-flow operation, where reactants (propene and parahydrogen) are simultaneously loaded for homogeneous or heterogeneous pairwise addition of parahydrogen, here a batch-mode method is applied: propene is first loaded into the catalyst-containing solution, which is followed by homogeneous hydrogenation via parahydrogen bubbling delivered at ≈7.1 atm. The achieved nuclear spin polarization of this contrast agent potentially useful for pulmonary imaging is approximately two orders of magnitude greater than that achieved in the continuous-flow homogeneous catalytic hydrogenation, and a factor of 3–10 more efficient compared to the typical results of heterogeneous continuous-flow hydrogenations.