Human upper airway epithelium produces nitric oxide in response to Staphylococcus epidermidis

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• 作者：Ryan M. Carey ; Bei Chen ; Nithin D. Adappa ; James N. Palmer ; David W. Kennedy ; Robert J. Lee and Noam A. Cohen
• 刊名：International Forum of Allergy & Rhinology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：12
• 页码：1238-1244
• 全文大小：472K
• ISSN：2042-6984

文摘

Nitric oxide (NO) is produced by sinonasal epithelial cells as part of the innate immune response against bacteria. We previously described bitter-taste-receptor-dependent and -independent NO responses to product(s) secreted by Pseudomonas aeruginosa and Staphylococcus aureus, respectively. We hypothesized that sinonasal epithelium would be able to detect the gram-positive, coagulase-negative bacteria Staphylococcus epidermidis and mount a similar NO response.