Chiral separation of benzothiazole derivatives of amino acids using capillary zone electrophoresis

详细信息    查看全文

• 作者：Zuzana Nová ; ková ; Vladimí ; r Pejchal ; Jan Fischer and Petr Česla
• 刊名：Journal of Separation Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：3
• 页码：798-803
• 全文大小：612K
• ISSN：1615-9314

文摘

A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin (CD) system. The best resolution of enantiomers was achieved in 100 mmol/L phosphate background electrolyte (pH 3.5) with the dual CD system consisting of 10 mmol/L of β-CD with 10 mmol/L of 2-hydroxypropyl-β-cyclodextrin for leucine derivative and 10 mmol/L of 2-hydroxypropyl-γ-cyclodextrin for phenylalanine derivative, respectively. Under the optimal conditions, the highest enantioresolution of 1.25 was achieved in a noncoated-fused silica capillary at 17°C and 24 kV applied voltage.