Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives
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- 作者：Hugh S. O' ; Neill ; Laura B. Gallagher ; Janice O' ; Sullivan ; William Whyte ; Clive Curley ; Eimear Dolan ; Aamir Hameed ; Joanne O' ; Dwyer ; Christina Payne ; Daniel O' ; Reilly ; Eduardo Ruiz-Hernandez ; Ellen T. Roche ; Fergal J O' ; Brien ; Sally Ann Cryan ; Helena Kelly ; Bruce Murphy and Garry P. Duffy
- 刊名：Advanced Materials
- 出版年：2016
- 出版时间：July 20, 2016
- 年：2016
- 卷：28
- 期：27
- 页码：5648-5661
- 全文大小：3793K
- ISSN：1521-4095
文摘
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.