The Caenorhabditis elegans Q neuroblasts: A powerful system to study cell migration at single-cell resolution in vivo
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- 作者：Lorenzo Rella ; Euclides E. Fernandes Pó ; voa and Hendrik C. Korswagen
- 关键词：C. elegans ; cell migration ; cell polarity ; neuroblast ; Wnt signaling
- 刊名：genesis
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：54
- 期：4
- 页码：198-211
- 全文大小：593K
- ISSN：1526-968X
文摘
During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer cell metastasis. In this article, we discuss the Caenorhabditis elegans Q neuroblasts and their descendants as a tool to study cell migration at single-cell resolution in vivo. The highly stereotypical migration of these cells provides a powerful system to study the dynamic cytoskeletal processes that drive migration as well as the evolutionarily conserved signaling pathways (including different Wnt signaling cascades) that guide the cells along their specific trajectories. Here, we provide an overview of what is currently known about Q neuroblast migration and highlight the live-cell imaging, genome editing, and quantitative gene expression techniques that have been developed to study this process. genesis, 2016.