Case of Pediatric Bullous Systemic Lupus Erythematosus Treated with Intravenous Immunoglobulin

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• 作者：Margit Juhá ; sz ; Megan Rogge ; Mary Chen ; Annette Czernik ; Soo Jung Kim and Lauren Geller
• 刊名：Pediatric Dermatology
• 出版年：2017
• 出版时间：January/February 2017
• 年：2017
• 卷：34
• 期：1
• 页码：e54-e56
• 全文大小：186K
• ISSN：1525-1470

文摘

This is a case report of a 16-year-old girl recently diagnosed with systemic lupus erythematosus (SLE) who presented with multiple blisters on the face, hands, arms, legs, trunk, and vaginal and oral mucosa. Skin biopsy was consistent with bullous SLE (BSLE). Dapsone is often the first-line treatment option for BSLE, but the patient's history of anemia and leukopenia and long-term immunosuppression requirement for her systemic symptoms raised concerns about dapsone and bone marrow toxicity, especially hemolytic anemia and agranulocytosis. She was started on intravenous immunoglobulin (IVIG), 2 g/kg divided over 3 days, with significant improvement in her cutaneous symptoms. IVIG is a treatment option for BSLE patients in whom agents such as dapsone are contraindicated.