Induction, management, and complications of streptozotocin-induced diabetes mellitus in rhesus monkeys
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- 作者：Jong-Min Kim ; Jun-Seop Shin ; Byoung-Hoon Min ; Hyun-Je Kim ; Jung-Sik Kim ; Il-Hee Yoon ; Won-Young Jeong ; Ga-Eul Lee ; Min-Sun Kim ; Ju-Eun Kim ; Sang-Man Jin and Chung-Gyu Park
- 刊名：Xenotransplantation
- 出版年：2016
- 出版时间：November/December 2016
- 年：2016
- 卷：23
- 期：6
- 页码：472-478
- 全文大小：775K
- ISSN：1399-3089
文摘
Diabetes mellitus (DM) model using streptozotocin (STZ) which induces chemical ablation of β cell in the pancreas has been widely used for various research purposes in non-human primates. However, STZ has been known to have a variety of adverse effects such as nephrotoxicity, hepatotoxicity, and even mortality. The purpose of this study is to report DM induction by STZ, toxicity associated with STZ and procedure and complication of exogenous insulin treatment for DM management in rhesus monkeys (Macaca mulatta) that are expected to be transplanted with porcine islets within 2 months.