Design and Synthesis of Novel Quinoline Tethered Tricyclic 1,5-Benzothiazepine Derivatives via 1,3-Dipolar Cycloaddition Reaction

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• 作者：Peng Yang ; Hui Lin ; Tinghong Fei and Fangming Liu
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：517-523
• 全文大小：1014K
• ISSN：1943-5193

文摘

A series of novel substituted-[1,2,4]oxadiazolo[5,4-d][1,5]benzothiazepine derivatives contain quinoline ring het2614-eo-0012" rel="references:#jhet2614-eo-0012 #jhet2614-eo-0013 #jhet2614-eo-0014 #jhet2614-eo-0015 #jhet2614-eo-0016 #jhet2614-eo-0017 #jhet2614-eo-0018 #jhet2614-eo-0019 #jhet2614-eo-0020 #jhet2614-eo-0021 #jhet2614-eo-0022 #jhet2614-eo-0023"> were synthesized by the reaction of benzothiazepines het2614-eo-0008" rel="references:#jhet2614-eo-0008 #jhet2614-eo-0009 #jhet2614-eo-0010"> and substituted-benzohydroximinoyl chlorides through the 1,3-dipolar cycloaddition reaction in the presence of Et₃N at room temperature. The structures of the obtained adducts were elucidated by MS, IR, ¹H NMR, and elemental analyses. In addition, the structures of het2614-eo-0016" rel="references:#jhet2614-eo-0016"> were further confirmed by X-ray single crystal diffraction study.