A Cooperative Strategy for the Highly Selective Intermolecular Oxycarbonylation Reaction of Alkenes using a Palladium Catalyst
详细信息 查看全文
- 作者：Ming Li ; Dr. Feng Yu ; Xiaoxu Qi ; Dr. Pinhong Chen and Prof. Dr. Guosheng Liu
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：October 24, 2016
- 年：2016
- 卷：55
- 期：44
- 页码：13843-13848
- 全文大小：1030K
- ISSN：1521-3773
文摘
A novel method for intermolecular functionalization of terminal and internal alkenes has been designed. The electrophilic reagent, hypervalent iodine, plays a key role in this process by activating the alkene C=C bond for nucleophilic addition of the palladium catalyst. This process generates an iodonium-containing palladium species which undergoes CO insertion. The new approach, intermolecular oxycarbonylaton reactions of alkenes, has been achieved and carried out under mild reaction conditions to produce the corresponding β-oxycarbonylic acids with excellent efficiencies and levels of regio- and diastereoselectivity.