Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy

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• 作者：Blanca del Rosal ; Alberto Pé ; rez-Delgado ; Elisa Carrasco ; Dragana J. Jovanović ; Miroslav D. Dramićanin ; Goran Dražić ; Á ; ngeles Juarranz de la Fuente ; Francisco Sanz-Rodriguez and Daniel Jaque
• 刊名：Advanced Optical Materials
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：4
• 期：5
• 页码：782-789
• 全文大小：2270K
• ISSN：2195-1071

文摘

Nanoparticle-mediated photothermal therapy (NP-PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy or chemotherapy. The future application of NP-PTT in real life mainly depends on the design and synthesis of novel multifunctional nanoparticles that could overcome the current limitations of NP-PTT such as limited penetration depth and absence of therapy control. In this work, ultrasmall (≈2.4 nm) NdVO₄ stoichiometric (100% constituent Nd³⁺ ions) nanoparticles are reported, which are capable of in vivo sub-tissue localized heating under 808 nm optical excitation while providing, simultaneously, the possibility of high penetration near-infrared fluorescence imaging. Ultrasmall stoichiometric NdVO₄ nanoparticles have evidenced a superior light-to-heat conversion efficiency. This is explained in terms of their large absorption cross-section at 808 nm (consequence of the particular spectroscopic properties of neodymium ions in NdVO₄ and of the high neodymium content) as well as to their ultrasmall size that leads to large nonradiative decay rates. Results included in this work introduce ultrasmall, NdVO₄ stoichiometric nanoparticles to the scientific community as multifunctional photothermal agents that could be considered as an alternative to traditional systems such as metallic, organic, or carbon-based nanoparticles.