High-salt diet induces outward remodelling of efferent arterioles in mice with reduced renal mass
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- 作者：L. Zhao ; Y. Gao ; X. Cao ; D. Gao ; S. Zhou ; S. Zhang ; X. Cai ; F. Han ; C. S. Wilcox ; L. Li and E. Y. Lai
- 刊名：Acta Physiologica
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：219
- 期：3
- 页码：652-659
- 全文大小：585K
- ISSN：1748-1716
文摘
The glomerular filtration rate (GFR) falls progressively in chronic kidney disease (CKD) which is caused by a reduction in the number of functional nephrons. The dysfunctional nephron exhibits a lower glomerular capillary pressure that is induced by an unbalance between afferent and efferent arteriole. Therefore, we tested the hypothesis that oxidative stress induced by CKD differentially impairs the structure or function of efferent vs. afferent arterioles.